2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-128700A
    Nicotinic acid mononucleotide triethylamine 99.89%
    Nicotinic acid mononucleotide triethylamine acts as a SARM1 inhibitor and a NAD+ biosynthesis intermediate, with an IC50 value of 93.3 μM against SARM1. Nicotinic acid mononucleotide triethylamine exerts axon-protective effects, delays axonal degeneration, elevates NAD+ levels, enhances Sirt1 activity, improves myocardial capillary density and alleviates myocardial fibrosis. Nicotinic acid mononucleotide triethylamine reverses diabetic cardiomyopathy in diabetic mice by increasing myocardial NAD+ levels. Nicotinic acid mononucleotide triethylamine is applicable to research related to cancer, multiple sclerosis, diabetic cardiomyopathy, neurodegenerative diseases and Huntington's disease.
    Nicotinic acid mononucleotide triethylamine
  • HY-145368B
    Tri-GalNAc(OAc)3-Perfluorophenyl
    Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation.Tri-GalNAc(OAc)3-Perfluorophenyl can be used for the study of liver metabolism.
    Tri-GalNAc(OAc)3-Perfluorophenyl
  • HY-B0143S3
    Niacin-13C6 1189954-79-7 ≥98.0%
    Niacin-13C6 is the 13C-labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.
    Niacin-13C6
  • HY-B0389S5
    D-Glucose-d2 18991-62-3 99.87%
    D-Glucose-d2 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-d2
  • HY-B0445AR
    NAD sodium (Standard) 20111-18-6 99.39%
    NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP.
    NAD sodium (Standard)
  • HY-B2219S6
    Stearic acid-d5 211443-83-3 98.90%
    Stearic acid-d55 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils.
    Stearic acid-d5
  • HY-N0230S2
    β-Alanine-d4 116173-67-2 99.90%
    β-Alanine-d4 is the deuterium labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
    β-Alanine-d4
  • HY-N0830S7
    Palmitic acid-d4 75736-49-1 99.88%
    Palmitic acid-d4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells.
    Palmitic acid-d4
  • HY-N1446S5
    Oleic acid-d9 2687960-84-3 ≥99.0%
    Oleic acid-d9 is deuterium labeled Oleic acid (HY-N1446). Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activato.
    Oleic acid-d9
  • HY-W001288
    Indole-4-carboxaldehyde 1074-86-8 ≥98.0%
    Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis.
    Indole-4-carboxaldehyde
  • HY-W005028
    1-Methylguanidine monohydrochloride 21770-81-0 98.0%
    1-Methylguanidine hydrochloride is an endogenous metabolite.
    1-Methylguanidine monohydrochloride
  • HY-W007330
    2-Bromoacetamide 683-57-8
    2-Bromoacetamide is a disinfection byproduct. 2-Bromoacetamide can inactivate liver alcohol dehydrogenase and interfere with microtubule and actin cytoskeletal function. 2-Bromoacetamide is a potent developmental toxicant in animals.
    2-Bromoacetamide
  • HY-W010410
    Oct-1-en-3-ol 3391-86-4 99.97%
    Oct-1-en-3-ol, a fatty acid fragrant, is a self-stimulating oxylipin messenger. Oct-1-en-3-ol serves as a signaling molecule in plant cellular responses, plant-herbivore interactions, and plant-plant interactions. Oct-1-en-3-ol causes dopamine neuron degeneration through disruption of dopamine handling.
    Oct-1-en-3-ol
  • HY-W011704
    Phosphoenolpyruvic acid cyclohexylammoniu​m salt 10526-80-4 ≥98.0%
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) cyclohexylammonium salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid cyclohexylammonium salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid cyclohexylammonium salt also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid cyclohexylammoniu​m salt
  • HY-W011711
    Benzarone 1477-19-6 ≥98.0%
    Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC50 value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases.
    Benzarone
  • HY-W012874
    D-Threonine 632-20-2 ≥98.0%
    D-Threonine (H-D-Thr-OH) is one of the important unnatural amino acids used as chiral building blocks in pharmaceutical drugs. D-Threonine is a metabolite of Saccharomyces cerevisiae. D-Threonine is cleaved into glycine and acetaldehyde by the catalytic action of D-threonine aldolase.
    D-Threonine
  • HY-W012922
    2-Methyl-4-pentenoic Acid 1575-74-2 99.75%
    2-Methyl-4-pentenoic Acid (2-Methylpent-4-enoic acid) is an organic acid that can be used as a precursor for synthesizing other compounds. Additionally, changes in the level of 2-Methyl-4-pentenoic Acid may be associated with the susceptibility to schizophrenia and type 2 diabetes.
    2-Methyl-4-pentenoic Acid
  • HY-W016773
    1,10-Decanediol 112-47-0 99.95%
    1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism. can be used as a surfactant/stabilizer in the synthesis of nanomaterials.
    1,10-Decanediol
  • HY-W018587
    TBPH 26040-51-7
    TBPH is a brominated flame retardant. TBPH enhances hepatic steatosis, inflammation, and fibrosis in mice with nonalcoholic steatohepatitis (NASH). TBPH induces dysregulation of phospholipid metabolism, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH leads to impaired endoplasmic reticulum-mitochondria (ER-Mito) contacts, subsequently causing mitochondrial dysfunction. TBPH induces lung injury through an inflammatory response mediated by mitochondria-derived ds-DNA. TBPH can be used to study the role of MFN2-mediated ER-mitochondria contacts in lipid metabolism homeostasis.
    TBPH
  • HY-W046906
    (E)-Oct-2-enoic acid 1871-67-6 98.33%
    (E)-Oct-2-enoic acid is an endogenous metabolite.
    (E)-Oct-2-enoic acid
Cat. No. Product Name / Synonyms Application Reactivity